Evaluation of Tumour Heterogeneity in the Initiation and Maintenance of Aml And Following Response to Therapy.

BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma

N Sejic, LC George, RJ Tierney, C Chang, O Kondrashova, RN MacKinnon, P Lan, AI Bell, G Lessene, HM Long, A Strasser, C Shannon-Lowe, GL Kelly

2020-10-13

Epstein-Barr virus (EBV)-associated T- and natural killer (NK)-cell malignancies, such as extranodal NK-/T-cell lymphoma (ENKTL), ..

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

L Fitzsimmons, R Cartlidge, C Chang, N Sejic, LCA Galbraith, CD Suraweera, D Croom-Carter, G Dewson, RJ Tierney, AI Bell, C Shannon-Lowe, MJ Herold, AB Rickinson, PM Colman, DCS Huang, A Strasser, M Kvansakul, M Rowe, GL Kelly

2020-05-01

Epstein–Barr virus (EBV), which is ubiquitous in the adult population, is causally associated with human malignancies. Like many i..

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

O Gilan, I Rioja, K Knezevic, MJ Bell, MM Yeung, NR Harker, EYN Lam, C Chung, P Bamborough, M Petretich, M Urh, SJ Atkinson, AK Bassil, EJ Roberts, D Vassiliadis, ML Burr, AGS Preston, C Wellaway, T Werner, JR Gray

2020-04-24

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate tran..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

ML Burr, CE Sparbier, KL Chan, YC Chan, A Kersbergen, EYN Lam, E Azidis-Yates, D Vassiliadis, CC Bell, O Gilan, S Jackson, L Tan, SQ Wong, S Hollizeck, EM Michalak, HV Siddle, MT McCabe, RK Prinjha, GR Guerra, BJ Solomon

2019-10-14

Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 sc..

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

L Fitzsimmons, AJ Boyce, W Wei, C Chang, D Croom-Carter, RJ Tierney, MJ Herold, AI Bell, A Strasser, GL Kelly, M Rowe

2018-02-01

While the association of Epstein-Barr virus (EBV) with Burkitt lymphoma (BL) has long been recognised, the precise role of the vir..

EBV and apoptosis: The viral master regulator of cell fate?

L Fitzsimmons, GL Kelly

2017-11-13

Epstein–Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma (BL), and is now known to be a contrib..

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8 T Cells in Human Lymphoid Organs

HG Woon, A Braun, J Li, C Smith, J Edwards, F Sierro, CG Feng, R Khanna, M Elliot, A Bell, AD Hislop, SG Tangye, AB Rickinson, T Gebhardt, WJ Britton, U Palendira

2016-08-01

Disruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein ..

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

GL Kelly, S Grabow, SP Glaser, L Fitzsimmons, BJ Aubrey, T Okamoto, LJ Valente, M Robati, L Tai, W Douglas Fairlie, EF Lee, MS Lindstrom, KG Wiman, DCS Huang, P Bouillet, M Rowe, AB Rickinson, MJ Herold, A Strasser

2014-01-01

The transcriptional regulator c-MYC is abnormally overexpressed in many human cancers. Evasion from apoptosis is critical for canc..

Different patterns of epstein-barr virus latency in endemic Burkitt Lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature

GL Kelly, W Wei Wenbin, W Thomas, D Croom-Carter, J Stylianou, C Woodman, AI Bell, AB Rickinson, J Rasaiyaah, P Kellam, C Kohler, R Spang

2013-03-01

Epstein-Barr virus (EBV) is present in all cases of endemic Burkitt lymphoma (BL) but in few European/North American sporadic BLs...